Pro-senescence therapy reduces joint inflammation

Pro-senescence therapy for hepatocellular carcinoma

(HCC) is one of the most frequent human malignancies with poor prognosis. Due to the current limitations of therapeutic options, there is a pressing need to elucidate the molecular mechanisms underlying human hepatocarcinogenesis and to identify novel targets for systemic therapy. It has recently been shown that Deleted in Liver Cancer 1 (DLC1), encoding a RhoGAP (Rho GTPase activating protein)...

Gene Therapy Approach: HSV-Enkephalin Reduces Fibrosis, Inflammation, and Pain

Senescence and the pro-tumorigenic stroma.

Hayflick and Moorhead first described senescence in the late 1960's as a permanent growth arrest that primary cells underwent after a defined number of cellular divisions in culture. This observation gave rise to the hypothesis that cells contained an internal counting mechanism that limited cellular division and that this limit was an important barrier to cellular transformation. What began as...

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

Interleukin (IL) 23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 affects memory T cell and inflammatory macrophage function through engagement of a novel receptor (IL-23R) on these cells. Recent analysis of the contribution of IL-12 and IL-23 to central nervous system autoimmune inflammation demonstrated that IL-23 rather than IL-12 was the essential...

[Crystal-induced joint inflammation].

The inflammatory response to microcrystals is one of the most powerful and intriguing examples of inflammation observable in man. Although many mechanisms of this reaction are well known, some aspects need to be further clarified, in particular those related to the self-limited nature of the process. Type and duration of the inflammatory reactions are mainly influenced by crystals characteristi...